E-ISSN 2587-0831
Original Article
Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors
1 Department of Radiation Oncology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey  
2 Department of Clinical Oncology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey  
3 Department of Public Health and Biostatistics, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey  
4 Department of Pathology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey  
Eur J Breast Health 2019; 15: 256-261
DOI: 10.5152/ejbh.2019.4778
Key Words: Breast cancer, Ki-67, prognostic factors, radiotherapy, survival
Abstract

 

Objective: The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factors in breast cancer patients.

 

Materials and Methods: Between 2010 and 2017, patients with invasive ductal carcinoma who received radiotherapy after surgery were included in study. A single pathologist re-defined of all cases retrospectively. Ki-67 were established three categories based on Ki-67 levels: low (<10%), intermediate (10-25%) and high (>25%).

 

Results: A total of 258 patients were included. 46 of 258 (18%) patients were in low, 82 of 258 (32%) patients were in intermediate and 130 of 258 (50%) patients were in high Ki-67 group. There were no correlations between menopausal status, age, and Ki-67 level. Low-pT stages tended to have low Ki-67 expression (p=0.07). Low-pN stages correlated with low Ki-67 values (p=0.007). Patients with ECE (+) were prone to have higher Ki-67 values (p=0.02). The significant correlation was seen between Ki-67 and tumour grading (p=<0.0001). Patients with LVI (+) had higher Ki-67 expression (p=0.007). Luminal A tumours were correlated with low Ki-67 group (p=<0.0001). Ki-67 values had significant effect on DFS (p=0.03) but not OS (p=0.09).

 

Conclusion: This study showed that high Ki-67 expression is associated with higher pT-stage, higher pN-stage, higher grade, ER/PR negativity, HER2/neu positivity, ECE and LVI positivity. The prognostic impact of Ki-67 was only demonstrated for DFS.

 

Cite this articles as: Kanyılmaz G, Benli Yavuz B, Aktan M, Karaağaç M, Uyar M, Fındık S. Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors. Eur J Breast Health 2019; 15(4): 256-261.

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