E-ISSN 2587-0831
Original Article
Diffusion-Weighted Imaging of Breast Cancer: Correlation of the Apparent Diffusion Coefficient Value with Pathologic Prognostic Factors
1 Department of Radiology, Koru Hospital, Ankara, Turkey  
2 Department of Radiology, Başkent University School of Medicine, Ankara, Turkey  
3 Department of Pathology, Başkent University School of Medicine, Ankara, Turkey  
4 Department of General Surgery, Başkent University School of Medicine, Ankara, Turkey  
Eur J Breast Health 2019; 15: 262-267
DOI: 10.5152/ejbh.2019.4860
Key Words: Breast cancer, diffusion-weighted imaging, apparent diffusion coefficient, prognostic factors
Abstract

 

Objective: The aim was to evaluate relationship between apparent diffusion coefficient (ADC) values with pathologic prognostic factors in breast carcinoma (BC).

 

Materials and Methods: 83 patients were enrolled in this study. Prognostic factors included age, tumor size, expression of estrogen receptor (ER) and progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), nuclear grade (NG), lymph node involvement and histologic type. The relationship between ADC and prognostic factors was determined using Independent sample t-test, ANOVA, Pearson correlation and relative operating characteristics (ROC) analysis.

 

Results: There was no significant difference between ADC and prognostic factors, including age, tumor size, ER, HER2 and histologic type. The PR-positive tumors (p=0.03) and axillary lymph node involvement (p=0.000) showed a significant association with lower ADC values. The ADC values were significantly lower in high-grade tumors than low-grade tumors (p=0.000). ROC analysis showed an optimal ADC threshold of 0.66 (×10-3 mm2/s) for differentiating low-grade tumors from high-grade tumors (sensitivity, 85.5%; specificity, 81%; area under curve, 0.90).

 

Conclusion: The lower ADC values of BC were significantly associated with positive expression of PR, LN positivity and high-grade tumor. Especially, ADC values were valuable in predicting NG subgroups. 

 

Cite this article as: Tezcan Ş, Uslu N, Ulu Öztürk F, Yılmaz Akçay E, Tezcaner T. Diffusion-Weighted Imaging of Breast Cancer: Correlation of the Apparent Diffusion Coefficient Value with Pathologic Prognostic Factors. Eur J Breast Health 2019; 15(4): 262-267.

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