ABSTRACT

The most of the breast cancer (BC) are initiated in the epithelial tissue of ductal system. Invasive ductal carcinoma occurs in a segmental fashion in the ductal system after the malignant transformation of ductal carcinoma insitu. The early detection of invasive carcinoma of the breast is possible with imaging systems. Especially mammography is gold standard for screening. However it’s not as sensitive in young women as postmenopausal women. Based on these reasons investigators interested in evaluating the ductal system. Ductoscopy, ductal lavage and nipple aspiration fluid (NAF) are evaluating methods of ductal system. These methods promise to detect the ductal system and pathologic cells in ductal fluid. On the other hand substances have been identified in ductal fluid which can be used for cancer detection. In this review, the new approaches with ductoscopy, ductal lavage and NAF were summarized in the light of the literature.