ABSTRACT

Prognostic factors are important in the follow-up of breast cancer patients and in the arrangement of adjuvant therapies. Purpose of this study was to determine the factors that eff ect overall and disease free survival in the patients with breast cancer in a long period of time in a single center.

Breast cancer patients who operated on Ankara Numune Research and Training Hospital at 4th Surgical Clinic, between January 1992 and January 2006 were investigated. There were 214 patients and the factors that eff ect overall and disease free survival rates were analyzed in univariate and multivariete survival analyses. Patients who undergone a modifi ed radical mastectomy and who have pathology report as infi ltrative ductal carcinoma were included in the study.

Mean follow-up time was 57 (12-192) months. Five years overall survival was 145 (133-157) months and five years disease free survival rate was 127 (113- 141) months. Locoregional recurrence rate was 9.3% (20 patients) and systemic recurrence rate was 27.5% (59 patients). General recurrence rate was 31.3% (67 patients). Grade and free tumor cell in axilla were the significant factors that effect overall survival rate and pN and grade were the significant factors that effect disease feee survival rate in multivariete analyses. Free tumor cell in axilla means that extramammary fatty tissues were infiltrated by tumor cells.

In patients with modifi ed radical mastectomy, grade and free tumor cell in axilla were the signifi cant factors that eff ect overall and disease survival rate beside the most popular factor nodal status.