ABSTRACT

Purpose:

To evaluate the treatment results of patients diagnosed with ductal carcinoma in situ (DCIS) treated with breast conserving surgery and adjuvant radiotherapy.

Materials and Methods:

Between 1991 and 2006, 46 patients were treated in Ege University Faculty of Medicine for DCIS, were analyzed retrospectively. All the patients underwent breast conserving surgery and adjuvant radiotherapy. Fifty Gy was delivered to whole breast through tangential portals. Boost dose was 10 Gy and it was given by photons in 3 (%10.7) patients and electrons in 25 (%89.3) patients.

Results:

Median age was 48 (range: 16-66). Of the patients, 45.6% (21) were diagnosed by screening mammography, the others were presented with palpable mass (50%), pain (2.2%) and discharge (2.2%). The most common tumor localization was upper outer quadrant (63%). Comedo histopathology was detected in 7 patients (15.2%).

After the surgery, cosmetic evaluation was as follows: 36.8% (14) excellent, 44.8% (17) good, 10.5% (4) satisfactory and 7.9% (3) fair. After radiotherapy cosmetic evaluation was performed at least 6 months after the end of treatment. The scores were found to be excellent in 34.2% (13) patients, good in 47.4% (18), satisfactory in 10.5% (4) and fair in 7.9% (3) patients (p=0.564).

Five and ten years disease free survival and local relaps free survival were 95.3%, 92.7% and 88.2%, 90.1%, respectively. Five and ten years overall survival 100% and for distant metastases free survival, these parameters were 100% and 88.3%, respectively.

Conclusion:

Partial mastectomy and adjuvant radiotherapy in the treatment of DCIS provides low recurrence rates and optimal cosmesis.