Research Article


  • Neslihan Cabıoğlu
  • Taylan Çelik
  • Vahit Özmen
  • Abdullah İğci
  • Mahmut Müslümanoğlu
  • Beyza Özçınar
  • Yasemin Özlük
  • Memduh Dursun
  • Temel Dağoğlu
  • Işık Aslay
  • Adnan Aydıner

Received Date: 21.02.2008 Accepted Date: 27.02.2008 Eur J Breast Health 2008;4(2):99-104

Phyllodes tumor of the breast is a rare fi broepithelial lesion. Between January 1993 and January 2008, 19 patients diagnosed with phyllodes tumor, were retrospectively analyzed in terms of demographic and clinicopathologic features and treatment modalities. The median age was 43 (range, 20-65). For diagnosis, 11 patients underwent excisional biopsy, 4 cases had incisional biopsies, and 4 patients had core biopsies/fi ne needle aspiration cytology. One patient with T4 tumor and lung metastasis was considered inoperable and received chemotherapy alone. Thirteen patients had breast conservative surgery (lumpectomy or reexcision), whereas 5 patients underwent mastectomy. The median tumor size was 7 cm (range, 2-21 cm). The pathologic classifi cation of the tumors was as follows: benign (n=6, 31.5%), borderline (n=6, 31.5%), and malignant (n=7, 37%). Among those with malignant phyllodes, 2 patients received chemotherapy and radiotherapy followed by mastectomy, and three patients with lumpectomy had radiotherapy. Median follow-up time was 36 months (4-108). One patient with malignant phylloides with mastectomy had lung metastases at the 24th month followed by chemotherapy&radiotherapy, and died of metastatic disease 3 months later. Furthermore, another patient with benign phyllodes who underwent lumpectomy with unknown surgical margins was found to have a local recurrence as benign phyllodes at the 37th month. No other recurrences were noted. The 5-year overall survival of patients with borderline&malign phyllodes was 83%. In conclusion, margin negative surgery plays a major role in the management of patients diagnosed with phyllodes tumors. However, the survival benefi t of adjuvant chemotherapy or radiation treatment warrants further investigation.

Keywords: phyllodes tumor, breast, surgery, radiation, chemotherapy