E-ISSN 2587-0831
Original Article
Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not?
1 Department of General Surgery, Okan University School of Medicine, İstanbul, Turkey;Department of General Surgery, Sakarya University Training and Research Hospital, Sakarya, Turkey  
2 Department of General Surgery, Sakarya University School of Medicine, Sakarya, Turkey; Department of General Surgery, İstinye University School of Medicine, İstanbul, Turkey  
3 Department of Pathology, Sakarya University Training and Research Hospital, Sakarya, Turkey  
4 Department of Microbiology, Sakarya University School of Medicine, Sakarya, Turkey  
5 Department of Pathology, İzmir Katip Çelebi University School of Medicine, İzmir, Turkey  
Eur J Breast Health ; : -
DOI: 10.5152/ejbh.2018.4249
Key Words: Mastitis, granulomatous mastitis, idiopathic granulomatous mastitis, bacteria, etiology
Abstract

Objective: Granulomatous mastitis is a rare, benign, chronic inflammatory disease of the breast of unknown etiology. This study evaluated bacteriologic agents that might play a role in the etiology of granulomatous mastitis using a molecular method with a universal primer after isolating deoxyribonucleic acid (DNA) from pathology specimens from patients diagnosed with granulomatous mastitis.


Materials and Methods
: Breast biopsy material in the pathology department obtained between July 2008 and June 2013 was analyzed. The history of the granulomatous mastitis patients was examined in detail and paraffin block sections of the biopsy material were used to determine the presence of bacteria with a universal DNA primer.


Results
: This study examined 45 granulomatous mastitis patients who had been diagnosed using excisional, incisional, or core biopsies. We evaluated multiple bacterial taxa, but obtained no positive result using a nucleic-acid-based assay with a universal primer.


Conclusion
: The etiology of idiopathic granulomatous mastitis remains unclear. Further studies with a large number of patients should aim to identify the causative agent.


Cite this article as
: Kıvılcım T, Altıntoprak F, Memiş B, Ferhatoğlu MF, Kartal A, Dikicier E, Çiftçi İH, Dilek FH. Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not? Eur J Breast Health 2018; 10.5152/ejbh.2018.4249

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