E-ISSN 2587-0831
Original Article
Correlation between 18F-FDG Positron-Emission Tomography 18F-FDG Uptake Levels at Diagnosis and Histopathologic and Immunohistochemical Factors in Patients with Breast Cancer
1 Department of Radiation Oncology, Acıbadem University School of Medicine Acıbadem Adana Hospital, Adana, Turkey  
2 Department of Internal Medicine, Acıbadem University School of Medicine Acıbadem Adana Hospital, Adana, Turkey  
3 Clinic of Medical Oncology, Acıbadem University School of Medicine Acıbadem Adana Hospital, Adana, Turkey  
4 Clinic of Medical Oncology, Acıbadem Adana Hospital, Adana, Turkey  
5 Clinic of Nuclear Medicine, Acıbadem Adana Hospital, Adana, Turkey; Department of Nuclear Medicine, Çukurova University School of Medicine, Adana, Turkey  
6 Clinic of Pathology, Acıbadem Adana Hospital, Adana, Turkey  
7 Clinic of General Surgery, Acıbadem Adana Hospital, Adana, Turkey  
Eur J Breast Health 2016; 12: 112-118
DOI: 10.5152/tjbh.2016.3031
Key Words: Breast cancer, positron-emission tomography, 18F-FDG, predictive, prognosis
Abstract

Objective: In this study, we aimed to determine the correlation between pretreatment-staging 18F-FDG total body positron-emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) levels and histopathologic and immunohistochemical predictive and prognostic factors in patients with breast cancer.

 

Materials and Methods: One hundred thirty-nine women with breast cancer who were treated between 2009 and 2015 at our hospital and who had pretreatment-staging PET/CT were included in the study. SUVmax levels and histopathologic and immunohistochemical results were compared.

 

Results: The median age of the women was 48 years (range, 29-79 years). The mean tumor volume was 33.4 mm (range, 0.7-120 mm). The histology was invasive ductal carcinoma in 80.6% of the patients. In the univariate analysis, SUVmax levels were significantly higher in patients with invasive ductal carcinoma; in patients with a maximum tumor diameter more than 2 cm; patients who were estrogen, progesterone, and combined hormone receptor-negative, triple-negative patients, and in tumors with higher grades (p<0.05). In HER2-positive patients, SUVmax levels were higher even if it was not statistically significant. There was no correlation between lymph node metastases and pathologic stage. In multivariate analysis, tumor diameter was an independent factor.

 

Conclusion: SUVmax levels are correlated with known histopathologic and immunohistochemical prognostic factors. PET/CT could be useful in preoperative evaluation of patients with breast cancer to predict biologic characteristics of tumors and prognosis.

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